Inhibition of soluble epoxide hydrolase by phytochemical constituents of the root bark of <i>Ulmus davidiana var. japonica</i>

A novel compound 1 and nine known compounds (2–10) were isolated by open column chromatography analysis of the root bark Ulmus davidiana. Pure (1–10) tested in vitro to determine inhibitory activity catalytic reaction soluble epoxide hydrolase (sEH). Compounds 1, 2, 4, 6–8, 10 had IC50 values ranging from 11.4 ± 2.3 36.9 2.6 μM. We used molecular docking simulate inhibitor binding each estimated pose site sEH. From this analysis, 2 was revealed be a potential sEH silico. Additionally, dynamics (MD) study performed find detailed interaction signals with enzyme. Finally, is promising candidates for development new natural plants.